EU:中、高危前列腺癌根治性前列腺切除术中扩大或局限盆腔淋巴结清扫术的价值

2021-09-26 泌尿小王 MedSci原创

中、高危前列腺癌根治性前列腺切除术中扩大或局限盆腔淋巴结清扫术在短期内对患者的预后没有明显差异。

自20世纪80年代开始推广盆腔淋巴结清扫术以来,盆腔淋巴结清扫术(PLND)已成为根治性前列腺切除术(RP)治疗前列腺癌(PCa)的不可分割的一部分。尽管影像学有了进展,但是PLND仍然是淋巴结分期的金标准方式。关于PLND的范围应该有多广,仍然存在重大争论。一些研究也提示发现阳性盆腔淋巴结的几率与PLND的程度成正比。扩大盆腔淋巴结清扫术(EPLND)在前列腺癌(PCa)患者手术治疗中的作用仍然存在争议,主要是因为缺乏随机对照试验。

 

近日《欧洲泌尿外科杂志》发表了一项研究,探讨EPLND是否优于局限性PLND (LPLND)。结果提示,扩大淋巴结切除并没有在预期范围内减少前列腺癌的生化复发

研究方法

这是一项前瞻性的、单中心3期试验,在中度或高风险的临床局限性PCa患者中进行。

干预随机分组(1:1)至双侧LPLND(闭孔淋巴结)或EPLND(闭孔、髂外、髂内、髂总、骶前淋巴结)。

主要结果为生化无复发生存期(BRFS)。

次要结果为无转移生存期(MFS)、肿瘤特异性生存期(CSS)和组织病理学结果。

同时该试验旨在显示EPLND对5年BRFS最小15%的优势。

 

结果

2012年5月至2016年12月,共随机选取300例患者(150例LPLND和150例EPLND)。

BRFS,MFS在两组无统计学差异。

CSS数据无法获得,因为在截止日期前没有患者死于PCa。

 

在亚组分析中,术前活检的国际泌尿外科病理学会(ISUP)分级3-5级患者接受EPLND能获取更长的BRFS (HR 0.33, 95% CI 0.14- 0.74,p = 0.007)。

 

研究结论

RCT证实EPLND具有较好的病理分期,但早期肿瘤预后没有差异。亚组分析提示在ISUP分级为3 ~ 5的患者中接受EPLND能延长BCRFS

 

评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1877484, encodeId=258918e74842b, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Oct 23 18:07:47 CST 2021, time=2021-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973359, encodeId=510a19e335914, content=<a href='/topic/show?id=b7d8660203a' target=_blank style='color:#2F92EE;'>#淋巴结清扫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66020, encryptionId=b7d8660203a, topicName=淋巴结清扫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac782500066, createdName=12498768m13(暂无昵称), createdTime=Fri Nov 26 02:07:47 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708892, encodeId=ad751e0889229, content=<a href='/topic/show?id=ffca32501e6' target=_blank style='color:#2F92EE;'>#前列腺切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32501, encryptionId=ffca32501e6, topicName=前列腺切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbe731571573, createdName=1249898am25暂无昵称, createdTime=Fri Sep 02 09:07:47 CST 2022, time=2022-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293137, encodeId=a3e3129313e1e, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586258, encodeId=1cde158625856, content=<a href='/topic/show?id=38f8622191b' target=_blank style='color:#2F92EE;'>#根治#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62219, encryptionId=38f8622191b, topicName=根治)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26d917348678, createdName=jeanqiuqiu, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590180, encodeId=d7b7159018067, content=<a href='/topic/show?id=c86e66021c9' target=_blank style='color:#2F92EE;'>#淋巴结清扫术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66021, encryptionId=c86e66021c9, topicName=淋巴结清扫术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dec17785365, createdName=kord1988, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=)]
    2021-10-23 doctorzheng

    #切除术#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1877484, encodeId=258918e74842b, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Oct 23 18:07:47 CST 2021, time=2021-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973359, encodeId=510a19e335914, content=<a href='/topic/show?id=b7d8660203a' target=_blank style='color:#2F92EE;'>#淋巴结清扫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66020, encryptionId=b7d8660203a, topicName=淋巴结清扫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac782500066, createdName=12498768m13(暂无昵称), createdTime=Fri Nov 26 02:07:47 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708892, encodeId=ad751e0889229, content=<a href='/topic/show?id=ffca32501e6' target=_blank style='color:#2F92EE;'>#前列腺切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32501, encryptionId=ffca32501e6, topicName=前列腺切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbe731571573, createdName=1249898am25暂无昵称, createdTime=Fri Sep 02 09:07:47 CST 2022, time=2022-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293137, encodeId=a3e3129313e1e, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586258, encodeId=1cde158625856, content=<a href='/topic/show?id=38f8622191b' target=_blank style='color:#2F92EE;'>#根治#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62219, encryptionId=38f8622191b, topicName=根治)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26d917348678, createdName=jeanqiuqiu, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590180, encodeId=d7b7159018067, content=<a href='/topic/show?id=c86e66021c9' target=_blank style='color:#2F92EE;'>#淋巴结清扫术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66021, encryptionId=c86e66021c9, topicName=淋巴结清扫术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dec17785365, createdName=kord1988, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1877484, encodeId=258918e74842b, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Oct 23 18:07:47 CST 2021, time=2021-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973359, encodeId=510a19e335914, content=<a href='/topic/show?id=b7d8660203a' target=_blank style='color:#2F92EE;'>#淋巴结清扫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66020, encryptionId=b7d8660203a, topicName=淋巴结清扫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac782500066, createdName=12498768m13(暂无昵称), createdTime=Fri Nov 26 02:07:47 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708892, encodeId=ad751e0889229, content=<a href='/topic/show?id=ffca32501e6' target=_blank style='color:#2F92EE;'>#前列腺切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32501, encryptionId=ffca32501e6, topicName=前列腺切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbe731571573, createdName=1249898am25暂无昵称, createdTime=Fri Sep 02 09:07:47 CST 2022, time=2022-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293137, encodeId=a3e3129313e1e, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586258, encodeId=1cde158625856, content=<a href='/topic/show?id=38f8622191b' target=_blank style='color:#2F92EE;'>#根治#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62219, encryptionId=38f8622191b, topicName=根治)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26d917348678, createdName=jeanqiuqiu, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590180, encodeId=d7b7159018067, content=<a href='/topic/show?id=c86e66021c9' target=_blank style='color:#2F92EE;'>#淋巴结清扫术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66021, encryptionId=c86e66021c9, topicName=淋巴结清扫术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dec17785365, createdName=kord1988, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1877484, encodeId=258918e74842b, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Oct 23 18:07:47 CST 2021, time=2021-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973359, encodeId=510a19e335914, content=<a href='/topic/show?id=b7d8660203a' target=_blank style='color:#2F92EE;'>#淋巴结清扫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66020, encryptionId=b7d8660203a, topicName=淋巴结清扫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac782500066, createdName=12498768m13(暂无昵称), createdTime=Fri Nov 26 02:07:47 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708892, encodeId=ad751e0889229, content=<a href='/topic/show?id=ffca32501e6' target=_blank style='color:#2F92EE;'>#前列腺切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32501, encryptionId=ffca32501e6, topicName=前列腺切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbe731571573, createdName=1249898am25暂无昵称, createdTime=Fri Sep 02 09:07:47 CST 2022, time=2022-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293137, encodeId=a3e3129313e1e, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586258, encodeId=1cde158625856, content=<a href='/topic/show?id=38f8622191b' target=_blank style='color:#2F92EE;'>#根治#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62219, encryptionId=38f8622191b, topicName=根治)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26d917348678, createdName=jeanqiuqiu, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590180, encodeId=d7b7159018067, content=<a href='/topic/show?id=c86e66021c9' target=_blank style='color:#2F92EE;'>#淋巴结清扫术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66021, encryptionId=c86e66021c9, topicName=淋巴结清扫术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dec17785365, createdName=kord1988, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=)]
    2021-09-28 sodoo
  5. [GetPortalCommentsPageByObjectIdResponse(id=1877484, encodeId=258918e74842b, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Oct 23 18:07:47 CST 2021, time=2021-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973359, encodeId=510a19e335914, content=<a href='/topic/show?id=b7d8660203a' target=_blank style='color:#2F92EE;'>#淋巴结清扫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66020, encryptionId=b7d8660203a, topicName=淋巴结清扫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac782500066, createdName=12498768m13(暂无昵称), createdTime=Fri Nov 26 02:07:47 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708892, encodeId=ad751e0889229, content=<a href='/topic/show?id=ffca32501e6' target=_blank style='color:#2F92EE;'>#前列腺切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32501, encryptionId=ffca32501e6, topicName=前列腺切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbe731571573, createdName=1249898am25暂无昵称, createdTime=Fri Sep 02 09:07:47 CST 2022, time=2022-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293137, encodeId=a3e3129313e1e, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586258, encodeId=1cde158625856, content=<a href='/topic/show?id=38f8622191b' target=_blank style='color:#2F92EE;'>#根治#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62219, encryptionId=38f8622191b, topicName=根治)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26d917348678, createdName=jeanqiuqiu, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590180, encodeId=d7b7159018067, content=<a href='/topic/show?id=c86e66021c9' target=_blank style='color:#2F92EE;'>#淋巴结清扫术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66021, encryptionId=c86e66021c9, topicName=淋巴结清扫术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dec17785365, createdName=kord1988, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=)]
    2021-09-28 jeanqiuqiu

    #根治#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1877484, encodeId=258918e74842b, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sat Oct 23 18:07:47 CST 2021, time=2021-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973359, encodeId=510a19e335914, content=<a href='/topic/show?id=b7d8660203a' target=_blank style='color:#2F92EE;'>#淋巴结清扫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66020, encryptionId=b7d8660203a, topicName=淋巴结清扫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac782500066, createdName=12498768m13(暂无昵称), createdTime=Fri Nov 26 02:07:47 CST 2021, time=2021-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708892, encodeId=ad751e0889229, content=<a href='/topic/show?id=ffca32501e6' target=_blank style='color:#2F92EE;'>#前列腺切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32501, encryptionId=ffca32501e6, topicName=前列腺切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbe731571573, createdName=1249898am25暂无昵称, createdTime=Fri Sep 02 09:07:47 CST 2022, time=2022-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293137, encodeId=a3e3129313e1e, content=<a href='/topic/show?id=df626600877' target=_blank style='color:#2F92EE;'>#淋巴结#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66008, encryptionId=df626600877, topicName=淋巴结)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586258, encodeId=1cde158625856, content=<a href='/topic/show?id=38f8622191b' target=_blank style='color:#2F92EE;'>#根治#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62219, encryptionId=38f8622191b, topicName=根治)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26d917348678, createdName=jeanqiuqiu, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590180, encodeId=d7b7159018067, content=<a href='/topic/show?id=c86e66021c9' target=_blank style='color:#2F92EE;'>#淋巴结清扫术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66021, encryptionId=c86e66021c9, topicName=淋巴结清扫术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dec17785365, createdName=kord1988, createdTime=Tue Sep 28 01:07:47 CST 2021, time=2021-09-28, status=1, ipAttribution=)]
    2021-09-28 kord1988

相关威廉亚洲官网

EU:双极雄激素对接受阿比特龙或恩杂鲁胺患者治疗后的应用价值

双极雄激素对接受阿比特龙或恩杂鲁胺患者治疗后的应用价值

J Urol:前列腺癌中系统活检与MRI靶向活检的检出率比较

比较了系统、MRI靶向和联合活检的PCa检出率,并对重要的亚组队列进行了评估。

OXID MED CELL LONGEV:不止提神又美味,这种打工人“完美饮料”还能抗癌!

综述:咖啡作为抗癌饮料的十年研究。含or不含咖啡因更好?喝多少杯合适?该注意什么?齐活!

J Urol:影响前列腺癌患者从主动监测转变为治疗的因素

调查了与男性前列腺癌患者从主动监测转为治疗时间间隔有关的人口统计学和临床病理学参数。

Eur Urol:Avelumab联合SABR是否能促进转移去势抵抗性前列腺癌的疗效?

评估了PD-L1抑制剂alvumab与立体定向消融体放疗(SABR)联用对mCRPC的疗效和安全性。

EU:评估哪些mCRPC患者更适合阿比特龙的模型

评估哪些mCRPC患者更适合阿比特龙的模型

拓展阅读

JAMA Netw Open:人工智能辅助MRI识别前列腺癌的临床价值

AI支持不仅提升了总体诊断性能,尤其在灵敏度和特异性两方面同步优化,还能缩小不同经验医师之间的表现差距,助推诊断均质化。

N Engl J Med:多基因风险评分辅助筛查前列腺癌:精准筛查新策略初显成效

BARCODE1为前列腺癌精准筛查策略提供了宝贵临床循证基础,推动基于遗传风险的筛查工具向临床转化,同时也为降低过度诊断与治疗奠定了基础。

Eur Urol Updates:精准医疗时代下的前列腺癌管理,大规模MRI引导主动监测研究揭示疾病进展预测新指标

前列腺癌是男性常见恶性肿瘤,主动监测作为低至中危患者的重要管理策略,旨在延缓或避免过度治疗相关的副作用。

Eur Urol Open Sci:精准诊断新突破,瑞典两地前列腺癌筛查中MRI中央复核提升诊断准确率

这项研究精彩揭示了去中心化前列腺癌筛查体系中,MRI图像评估的“瓶颈”问题以及中央复核的重要价值。

夜尿多?针灸疗法“破局”!IF 22.3,JAMA子刊:针刺疗法改善前列腺癌夜尿频繁,提升整体泌尿功能

该研究首次探讨了针灸在前列腺癌幸存者夜尿症治疗中的应用,并取得了令人瞩目的成果。

苏大李盛亮团队《AFM》:“光+药”组合攻克“冷肿瘤”前列腺癌

苏州大学团队构建 PSMA 靶向纳米平台,实现 NIR-II 成像引导的 ROS 自增强型 I 型光动力疗法,攻克前列腺癌治疗中缺氧与抗氧化难题,有效抑制肿瘤并延长荷瘤小鼠生存期。

2025 CUA/CUOG威廉亚洲博彩公司 :未接受过去势治疗和去势敏感性转移性前列腺癌(更新版)

加拿大泌尿外科协会(CUA,Canadian Urological Association) · 2025-05-19

2025 ASCO威廉亚洲博彩公司 更新:转移性去势抵抗性前列腺癌患者的全身治疗

美国临床肿瘤学会(ASCO,American Society of Clinical Oncology) · 2025-05-02

精准医学时代前列腺癌营养管理中国专家共识

中国泌尿外科相关专家组(统称) · 2025-04-02