Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death

Fresquet, V; Garcia-Barchino, MJ; Larrayoz, M; Celay, J; Vicente, C; Fernandez-Galilea, M; Larrayoz, MJ; Calasanz, MJ; Panizo, C; Junza, A; Han, JH; Prior, C; Fortes, P; Pio, R; Oyarzabal, J; Martinez-Baztan, A; Paiva, B; Moreno-Aliaga, MJ; Odero, MD; Agirre, X; Yanes, O; Prosper, F; Martinez-Climent, JA

Fresquet, V; Martinez-Climent, JA (corresponding author), Univ Navarra, Div Hematol, Ctr Appl Med Res CIMA, Sch Med, Avda Pio XII 55, Pamplona 31008, Spain.

CANCER DISCOVERY, 2021; 11 (5): 1268

Abstract

For millions of years, endogenous retroelements have remained transcriptionally silent within mammalian genomes by epigenetic mechanisms. Modern antic......

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