Thyroid hormone receptor beta sumoylation is required for thyrotropin regulation and thyroid hormone production

Ke, SJ; Liu, YY; Karthikraj, R; Kannan, K; Jiang, JJ; Abe, K; Milanesi, A; Brent, GA

Liu, YY; Brent, GA (corresponding author), Dept Med, Div Endocrinol Diabet & Metab, 10833 Conte Ave,57-143 CHS, Los Angeles, CA 90095 USA.

JCI INSIGHT, 2021; 6 (16):

Abstract

Thyroid hormone receptor beta (THRB) is posttranslationally modified by small ubiquitin-like modifier (SUMO). We generated a mouse model with a mutati......

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