J Dev Orig Health Dis:母婴压力之间的关系在孩子11岁时“见分晓”

2018-12-11 佚名 中国生物技术网

近日发表在《健康与疾病发展起源》上的一项研究发现,母亲在怀孕时的压力水平与其子女在11岁时应对生活挑战的方式有关。该研究是加拿大西蒙弗雷泽大学SFU健康科学教授Pablo Nepomnaschy领导的跨学科研究团队首次完成的前瞻性队列研究。

近日发表在《健康与疾病发展起源》上的一项研究发现,母亲在怀孕时的压力水平与其子女在11岁时应对生活挑战的方式有关。该研究是加拿大西蒙弗雷泽大学SFU健康科学教授Pablo Nepomnaschy领导的跨学科研究团队首次完成的前瞻性队列研究。

在该研究中,研究人员测量了怀孕前母亲的皮质醇水平,并持续到妊娠的前八周。然后在多年之后对其子女也进行了测量。他们的目的是了解怀孕期间母体的生理应激与其子女应激生理发展之间的关系。

研究人员利用尿液样本测量生殖激素,确定了女性怀孕的那一天,并在她们怀孕后的前8周测量其皮质醇水平,皮质醇是生理应激的生物标志物。

十二年后,他们研究了这些儿童对新学年的反应(一种已知的自然压力),以及公开演讲(一种被频繁使用的实验性压力)时的反应。

结果显示,母亲在怀孕期间的皮质醇水平与其子女面对挑战时的皮质醇反应不同方面存在关联,而且这些关联在男孩和女孩之间还存在差异。

该研究第一作者Cindy Barha说,母亲在妊娠第二周皮质醇水平较高,她的儿子对实验性公开演讲挑战的反应也较高,但是并没有在女儿身上观察到这种相关性。相比之下,在妊娠第五周时皮质醇水平较高的母亲在新学期开始前,其女儿的“基础”皮质醇水平较高,在男孩身则不存在这种情况。

然而,如果母亲在妊娠第五周期间皮质醇水平较高,那么其子女在面临新学期开始和实验性公开演讲之前的皮质醇反应都较高。研究人员表示,介导这些联系的生物学机制尚不清楚,但可能涉及遗传学和表观遗传学以及母亲及其子女共有的环境和文化因素。

Nepomnaschy说:“压力不仅对儿童应对社会和学术挑战的能力起着关键作用,而且还对其成年发展和健康产生重要影响。”研究人员将继续调查从受孕时起母婴压力之间的关系。这些发现将有助于制定成功的计划和干预措施,使儿童能够过上健康和充实的生活,并充分发挥他们的潜力。

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    2019-02-04 fzwish20000
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    2019-10-11 shizhenshan
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    2018-12-13 zhouqu_8
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    2018-12-12 haige

    总之压力高不是好事。

    0

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