Nat Commun:急性心肌梗死和致命性冠心病相关饮食因素的系统综合纵向评价

2020-11-28 haibei MedSci原创

其应用环境全域关联研究的方法,对护士健康研究数据进行全面、敏捷地探索,研究了257种营养素和117种食物与冠心病风险(急性心肌梗死和致命性冠心病)的关联。

心脏病是全世界死亡的主要原因,其发病率受到饮食和饮食习惯的强烈影响。例如,在最近的一份CDC(疾病控制和预防中心)报告中,其重点关注美国各地由心脏病引起的死亡率,记录了与不同饮食模式相适应的巨大区域差异。同样,在日本后裔中,虽然冠心病(CHD)的发病率在日本只有1.6/人年,但在夏威夷却增加到3.0,在旧金山增加到3.76,这些差异不能用遗传因素来解释,表明了饮食和其他环境因素在疾病发展中的关键作用。

以往每次研究的重点是单一营养素或食物的作用。最近,研究人员在Nature Communications杂志发文,其应用环境全域关联研究的方法,对护士健康研究数据进行全面、敏捷地探索,研究了257种营养素和117种食物与冠心病风险(急性心肌梗死和致命性冠心病)的关联。

在计入多重测试后,研究人员确定了16种食物和37种营养素显示出统计学意义上的关联。研究人员同时调整了潜在的混杂因素和控制变量,如体力活动、吸烟、卡路里摄入和药物使用,并发现其中38种关联在护士健康研究II中得到了验证。

研究人员实施的全环境关联研究成功重现了流行病学文献中关于饮食-冠心病关联的先前知识,并帮助他们发现了仅有少量研究的新关联,为进一步广泛的实验验证开辟了潜在途径。

研究人员还表明,全环境关联研究使人们能够识别出一个双向的食物-营养素网络,突出了哪些食物推动了特定营养素与冠心病风险的关联。

 

原始出处:

Soodabeh Milanlouei et al. A systematic comprehensive longitudinal evaluation of dietary factors associated with acute myocardial infarction and fatal coronary heart disease. Nature Communications (2020). 

 

评论区 (7)
#插入话题
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    2021-04-07 liuli5079

    #COMMUN#

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    2021-01-22 hittouch
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    2021-01-29 ms9000000881511632

    看来饮食调节也将成为预防冠心病的关键

    0

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    2021-01-20 147e4706m08暂无昵称

    学习了

    0

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    2021-01-20 147e4706m08暂无昵称

    学习了

    0

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    2021-02-17 liye789132251

    #Nat#

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    2020-11-30 huagfeg

    #评价#

    0

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