性别、种族和社会经济地位对慢性血栓栓塞性肺动脉高压肺动脉血栓内膜切除术后生存的影响

2022-07-12 刘少飞 MedSci原创

肺血栓切除术(PTE)是慢性血栓栓塞性肺动脉高压(CTEPH)的一种最终治疗方法。基于人口统计学的PTE结果的差异还没有得到很好的研究。

慢性血栓栓塞性肺动脉高压(CTEPH)是一种严重的肺动脉高压,如果不加以治疗,死亡率很高。肺血栓切除术(PTE)可以作为这种疾病的治愈性治疗,将CTEPH的3年生存率从70%提高到90%。与PTE术后不良预后相关的危险因素包括:肺动脉收缩压升高的严重程度、残余的肺血管高压、潜在的促血栓形成状况以及血栓在肺血管树内的定位深度。PTE后死亡的其他危险因素有:桥接肺动脉高压靶向治疗、纽约心脏协会IV级症状、癌症史和透析依赖性肾衰竭。肺血栓切除术(PTE)是慢性血栓栓塞性肺动脉高压(CTEPH)的一种最终治疗方法。基于人口统计学的PTE结果的差异还没有得到很好的研究。

研究方法:

williamhill asia 回顾了2009年至2019年期间在williamhill asia 机构接受PTE治疗CTEPH的所有患者,跟踪人口统计学信息,包括自我识别的种族、术前特征和2年生存率。社会经济地位(SES)使用与邮政编码相关的贫困社区指数进行评估,该指数是对社区福祉的有效整体衡量。存活率用Kaplan-Meier方法估计,与死亡率相关的因素用Cox回归法估计。

研究结果:

235名PTE患者中,101人(42.9%)是白人,87人(37.0%)是黑人。白人患者手术时的中位年龄较高(57岁对51岁,P=0.035),经济窘迫程度较低(33.6对61.2百分位,P<0.001)。关于性别,106名(45.1%)患者为男性,129名(53.6%)为女性。男性患者的中位年龄较高(59岁对50岁,P=0.004),血脂异常率较高(34%对20.2%,P=0.025),射血分数较低(55%对57%,P=0.046),交叉夹闭时间较长(77分钟对67.50分钟,P=0.004),循环停止时间较长(42对37.50分钟,P=0.007)。按种族和性别分层的患者在PTE后未经调整的2年生存率方面没有观察到差异(P = 0.35)。调整了临床相关的变量后,在Cox比例危险分析中,SES、性别或种族都与死亡率无关。

研究结论:

在williamhill asia 单一中心的经验中,性别、SES和种族与PTE后的不良结果无关。

 

参考文献:

Su AY, Vinogradsky A, Wang AS, Ning Y, Abrahams E, Bacchetta M, Kurlansky P, Rosenzweig EB, Takeda K. Impact of Sex, Race, and Socioeconomic Status on Survival after Pulmonary Thromboendarterectomy for Chronic Thromboembolic Pulmonary Hypertension. Eur J Cardiothorac Surg. 2022 Jul 9:ezac364. doi: 10.1093/ejcts/ezac364. Epub ahead of print. PMID: 35809067.

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    2023-04-01 jklm09
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  5. 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authenticateStatus=null, createdAvatar=null, createdBy=715e12724163, createdName=yangcx0919, createdTime=Wed Jul 13 05:53:42 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617099, encodeId=4716161e099b7, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Wed Jul 13 05:53:42 CST 2022, time=2022-07-13, status=1, ipAttribution=)]
    2023-04-03 s_pl2008
  6. 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    2023-04-03 医者仁心
  7. 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  8. 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time=2022-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457177, encodeId=f8a6145e1772a, content=<a href='/topic/show?id=94f5e400123' target=_blank style='color:#2F92EE;'>#社会经济地位#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74001, encryptionId=94f5e400123, topicName=社会经济地位)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c6025850709, createdName=chenwq10, createdTime=Wed Jul 13 05:53:42 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536831, encodeId=351f15368319b, content=<a href='/topic/show?id=fcbd3332949' target=_blank style='color:#2F92EE;'>#动脉血栓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33329, encryptionId=fcbd3332949, topicName=动脉血栓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=715e12724163, createdName=yangcx0919, createdTime=Wed Jul 13 05:53:42 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617099, encodeId=4716161e099b7, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Wed Jul 13 05:53:42 CST 2022, time=2022-07-13, status=1, ipAttribution=)]
    2022-07-13 chenwq10
  9. 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    2022-07-13 yangcx0919
  10. 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authenticateStatus=null, createdAvatar=null, createdBy=715e12724163, createdName=yangcx0919, createdTime=Wed Jul 13 05:53:42 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617099, encodeId=4716161e099b7, content=<a href='/topic/show?id=e660e3936c0' target=_blank style='color:#2F92EE;'>#社会#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73936, encryptionId=e660e3936c0, topicName=社会)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6de19781024, createdName=ms705947299214030, createdTime=Wed Jul 13 05:53:42 CST 2022, time=2022-07-13, status=1, ipAttribution=)]
    2022-07-13 ms705947299214030

    #社会#

    0

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广州医科大学附属第一医院

吸烟大于5.5年,高血压风险增加!中国健康与营养调查数据分析

吸烟累积暴露量<5.5包年的男士发生高血压的风险明显增加。

Hypertension:RAAS抑制剂可显著降低高血压患者脑动脉瘤的破裂风险

RAAS抑制剂可显著降低高血压患者脑动脉瘤的破裂风险

Stroke:中国成人血清左旋肉碱水平与高血压患者首次卒中相关

在这项针对中国农村成人高血压患者的研究中,血清左旋肉碱水平与首次卒中呈负相关但非线性关系。叶酸水平和MTHFR C677T突变是这种关联显著效应的调节因素。

Hypertension:高血压遗传易感性女性患先兆子痫的风险增加

HBP-PRS与先兆子痫、复发性先兆子痫和具有严重特征的先兆子痫的风险增加有关。此外,患有HBP-PRS的女性在妊娠期间表现出更高的血压。

JAHA:睡眠微观结构与高血压发病的关系

睡眠微结构与高血压发病相关。慢波活动和睡眠纺锤波是客观睡眠连续性和质量的两个标志,与高血压发生率呈负相关。