Targeting eIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer

Zhao, N; Kabotyanski, EB; Saltzman, AB; Malovannaya, A; Yuan, XY; Reineke, LC; Lieu, N; Gao, Y; Pedroza, DA; Calderon, SJ; Smith, AJ; Hamor, C; Safari, K; Savage, S; Zhang, B; Zhou, JL; Solis, LM; Hilsenbeck, SG; Fan, C; Perou, CM; Rosen, JM

Rosen, JM (通讯作者),Baylor Coll Med, BCM130,Rm BCM-M625E,1 Baylor Plaza, Houston, TX 77030 USA.

JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (24):

Abstract

Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA translation represents an attractive cancer therapy. Here, we ......

Full Text Link