Fragment-based drug design facilitates selective kinase inhibitor

Wang, ZZ; Shi, XX; Huang, GY; Hao, GF; Yang, GF

Hao, GF (corresponding author), Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.; Hao, GF (corresponding author), Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Peoples R China.; Hao, GF (corresponding author), Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Ctr Res & Dev Fine C

TRENDS IN PHARMACOLOGICAL SCIENCES, 2021; 42 (7): 551

Abstract

Protein kinases (PKs) are important drug targets, but kinases selectivity poses a challenge to protein kinase inhibitors (PKIs) design. Fragment-based......

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