Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system

Fujihira, Y; Liang, YM; Ono, M; Hirano, K; Kagawa, T; Shibata, N

Shibata, N (corresponding author), Nagoya Inst Technol, Dept Life Sci & Appl Chem, Showa Ku, Nagoya, Aichi 4665888, Japan.; Shibata, N (corresponding author), Nagoya Inst Technol, Dept Nanopharmaceut Sci, Showa Ku, Nagoya, Aichi 4665888, Japan.; Shibata, N (corresponding author), Zhejiang Normal Univ, Inst Adv Fluorine Containing Mat, 688 Yingbin Ave, Jinhua 321004, Zhejiang, Peoples R China.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2021; 17 (): 431

Abstract

A straightforward method that enables the formation of biologically attractive trifluoromethyl ketones from readily available methyl esters using the ......

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