Enzyme-mediated depletion of L-cyst(e)ine synergizes with thioredoxin reductase inhibition for suppression of pancreatic tumor growth

Kshattry, S; Saha, A; Gries, P; Tiziani, S; Stone, E; Georgiou, G; DiGiovanni, J

DiGiovanni, J (reprint author), Univ Texas Austin, Pediat Res Inst, Div Pharmacol & Toxicol, 1400 Barbara Jordan Blvd, Austin, TX 78723 USA.

NPJ PRECISION ONCOLOGY, 2019; 3 ():

Abstract

Perturbing redox homeostasis potentially constitutes a selective cancer-killing strategy. An engineered human enzyme, cyst(e)inase that degrades extra......

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