NEJM:Durvalumab可显著延长III期无法切除的非小细胞肺癌患者总生存期

2018-12-13 zhangfan MedSci原创

Durvalumab可显著延长III期无法切除的非小细胞肺癌患者总生存期

先前公布的研究结论表明, Durvalumab显著延长了III期无法切除的非小细胞肺癌(NSCLC)患者无进展生存期。近日研究人员公布了该研究另一个主要终点--总生存期结果。

患者在放化疗基础上,每2周接受1次durvalumab(10mg/kg)或安慰剂,持续12个月。研究的主要终点为无进展生存期和总生存期。

709名患者参与研究,其中durvalumab组473人,安慰剂组236人。随访25.2个月,durvalumab组24个月生存率为66.3%,对照组为55.6%(死亡HR=0.68)。durvalumab组无进展生存期为17.2个月,安慰剂组仅为5.6个月(进展或死亡HR=0.51)。durvalumab组死亡或远端转移的时间为28.3个月,安慰剂组为16.2个月。durvalumab组30.5%的患者出现3-4级不良事件,安慰剂组为26.1%。因不良事件导致的停药率分别为15.4%和9.8%。

研究认为,Durvalumab可显著延长III期无法切除的非小细胞肺癌患者总生存期。

原始出处:

Scott J. Antonia et al. Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC.N Engl J Med, December 13, 2018.

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    2019-02-13 juliusluan78
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