NEJM:红皮病和肺结节-病例报道

2018-12-13 MedSci MedSci原创

考虑到患者的吸烟史并且担心存在与皮炎相关的潜在肿瘤,进行了胸部X线片检查,发现左肺不透明。怀疑是副肿瘤性红皮病,并且胸部的计算机断层扫描证实左上叶存在肺结节

患者为一名73岁的男性,因持续性全身性皮疹偶尔出现瘙痒3个月而到皮肤科就诊。他没有任何先前的皮肤病或药物过敏史;他是一名吸烟者,吸烟史为40包年。


体格检查发现对称的全身性红斑性皮疹(如图A所示),手和脚上覆有鳞屑和脱屑。他最初接受局部糖皮质激素治疗,然后口服泼尼松和抗组胺药,而后静脉注射糖皮质激素,但没有缓解。皮肤活检显示轻微的棘皮症和角化不全伴有粒细胞浸润-这一发现与红皮病皮炎一致。考虑到患者的吸烟史并且担心存在与皮炎相关的潜在肿瘤,进行了胸部X线片检查,发现左肺阴影。怀疑是副肿瘤性红皮病,并且胸部的计算机断层扫描证实左上叶存在肺结节(如图B所示)。

患者接受了左肺上叶切除术和淋巴结清扫术。组织学检查显示中度分化的鳞状细胞癌。副肿瘤性红皮病是肺癌罕见的初始临床表现。它还可能与血液系统癌症和其他实体器官癌症有关。切除后一个月,患者皮疹完全消除(如图C所示)。一年后,他没有再出现过皮疹或肿瘤复发。

原始出处:


Luca Ampollini,et al.Erythroderma and a Pulmonary Nodule.N Engl J Med 2018;https://www.nejm.org/doi/full/10.1056/NEJMicm1802572

本文系williamhill asia 医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“williamhill asia 医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于williamhill asia 医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“williamhill asia 医学”。其它来源的文章系转载文章,或“williamhill asia 号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与williamhill asia 联系,williamhill asia 将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2003899, encodeId=a65f200389909, content=<a href='/topic/show?id=0a04e714467' target=_blank style='color:#2F92EE;'>#红皮病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77144, encryptionId=0a04e714467, topicName=红皮病)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Fri Nov 08 13:09:00 CST 2019, time=2019-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=361844, encodeId=ecd536184460, content=有意思的病例, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Sat Mar 02 15:27:28 CST 2019, time=2019-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355311, encodeId=01c935531125, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/y6Sk2KiaDibWSs0icexcRzKWXKao9dILdyaB6olvWApA1uiaapa4T9XMiaU7hTZA04uj2iavabfdCT5iaO6AYue5qSJ7MzXaAVSqh6j/0, createdBy=08e01983553, createdName=执迷不悔, createdTime=Thu Dec 13 14:23:02 CST 2018, time=2018-12-13, status=1, ipAttribution=)]
    2019-11-08 tastas
  2. [GetPortalCommentsPageByObjectIdResponse(id=2003899, encodeId=a65f200389909, content=<a href='/topic/show?id=0a04e714467' target=_blank style='color:#2F92EE;'>#红皮病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77144, encryptionId=0a04e714467, topicName=红皮病)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Fri Nov 08 13:09:00 CST 2019, time=2019-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=361844, encodeId=ecd536184460, content=有意思的病例, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Sat Mar 02 15:27:28 CST 2019, time=2019-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355311, encodeId=01c935531125, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/y6Sk2KiaDibWSs0icexcRzKWXKao9dILdyaB6olvWApA1uiaapa4T9XMiaU7hTZA04uj2iavabfdCT5iaO6AYue5qSJ7MzXaAVSqh6j/0, createdBy=08e01983553, createdName=执迷不悔, createdTime=Thu Dec 13 14:23:02 CST 2018, time=2018-12-13, status=1, ipAttribution=)]
    2019-03-02 laoli

    有意思的病例

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2003899, encodeId=a65f200389909, content=<a href='/topic/show?id=0a04e714467' target=_blank style='color:#2F92EE;'>#红皮病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77144, encryptionId=0a04e714467, topicName=红皮病)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Fri Nov 08 13:09:00 CST 2019, time=2019-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=361844, encodeId=ecd536184460, content=有意思的病例, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Sat Mar 02 15:27:28 CST 2019, time=2019-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355311, encodeId=01c935531125, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/y6Sk2KiaDibWSs0icexcRzKWXKao9dILdyaB6olvWApA1uiaapa4T9XMiaU7hTZA04uj2iavabfdCT5iaO6AYue5qSJ7MzXaAVSqh6j/0, createdBy=08e01983553, createdName=执迷不悔, createdTime=Thu Dec 13 14:23:02 CST 2018, time=2018-12-13, status=1, ipAttribution=)]
    2018-12-13 执迷不悔

    学习了

    0

相关威廉亚洲官网

BMJ:红皮病的重要原因-案例报道

在老年人红皮病的鉴别诊断上,除了更常见的原因,包括牛皮癣、湿疹和药物反应外,应重点考虑挪威疥又称结痂性疥疮或角化性疥疮。疥疮典型的皮肤症状可以缺失,如隧道皮损,生殖器上的结节,广泛的结痂斑块,瘙痒。